Microelectronics Seminar, UMCP 09/03/02 5pm Rm AVW 2328 Electrical Stimulation: An Overview Dr. Gideon Kantor Adjunct Associate Professor Biomedical Engineering Department Catholic University of America Because of the rapidly increasing use of electrical stimulation in the treatment of patients, it is purposeful to present an overview of transcutaneous and invasive therapeutic procedures. As to transcutaneous stimulation, critical parameters for safe and effective device performance, such as excitation sources and phase charge of various waveforms, are discussed within the framework of clinical studies. Clinical results showing a difference in response due to gender difference are also given. The performance of the only FDA approved functional electrical stimulator (FES) for paraplegic patients is reviewed. Implanted FES devices for limbs are considered. A short videotape of corrosion of lead wires of a leg implanted FES is shown, illustratin a catastrophic malfuncion due to a chemical reaction between metal and tissue. The design of a BION, a minituarized stimulator, implanted by a hyperthermic needle, is introduced. The use of recently developed implanted electrical stimulation devices is discussed for heart and stroke patients as well as for epileptic and Parkinson disease (PD) patients. For these PD patients, a deep brain stimulator (DPS) was recently developed which will be discussed in some detail in terms of its effectiveness. Finally the future of electrial stimulation is discussed with emphasis of the potential use of BION's in the treatment of patients requiring invasive treatments Brief Curriculum Vitae Dr. Kantor has all his degrees in electrical engineering with his Ph.D. from Cornell University. Earlier in his career he was involved in radiowave propagation and associated radar studies. For more than 20 years until he retired in 1995, his responbilities at FDA included laboratory performance evaluation of medical devices. Initially he participated in research studies of hyperthermia treatment of cancer by electromagnetically induced heating. Dr. Kantor was the Prinicpal Investigator of a NIH funded interagency agreement in support of developing a quality assurance program for hyperthemia devices at various hospitals throughout the the United States. Later on he got involved in clinical studies of electrical stimulators to determine their critical performance parameters related to their safety and effectiveness. Furthermore he got involved in a laboratory performance evaluation of implanted defibrillators. Many publications resulted from his various studies. Presently Dr. Kantor is Adjunct Asssociate Professor in the Biomedical Engineering Department of Catholic University where his teaching includes a course in neural stimulation in rehabilitation. He is a Non-affiliate Member of the FDA/OST Institutional Animal Care and Use Committee and a Member of the Advsiory Committee of a Harvard/MIT study on nonlinear biosignals. Dr Kantor is a Fellow of the IEEE and a Fellow of AIMBE.