Inflammation and Cholesterol: Friend Or Foe in Alzheimer's Disease
C. R. Kyrtsos and J. S. Baras
Proceedings of the SIAM Conference on the Life Sciences 2012, San Diego, California, August 7-10, 2012.
Alzheimer's disease (AD) is the most common form of dementia affecting the elderly, leading to debilitating memory loss and significant cognitive decline. The exact mechanism of pathogenesis is not well understood. Here, we present an organ level model that studies the role of cholesterol metabolism and inflammation in the early stages of AD, demonstrating the importance of brain cholesterol on the expression of beta amyloid. The model has been further validated with experimental data.