Jeong Kim Engineering Building, Rm. 1110
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Booz Allen Hamilton Distinguished Colloquium in Electrical and Computer Engineering
"Magnetic Nanotechnology Based Biochips — A New Tool for Cancer Diagnostics and Radiation Triage"
(Rescheduled from Feb. 5 due to weather)
Dr. Shan X. Wang
Professor of Materials Science and Electrical Engineering and Director of the Stanford Center for Magnetic Nanotechnology
Reproducible and multiplex protein assays are greatly desired by cancer biologists as well as clinical oncologists to rapidly follow numerous proteins in clinical samples. By simply applying patient serum or tissue samples to the magneto-nano sensor chip developed in our group, one can readily and quantitatively ascertain the presence or absence of a large number of tumor markers, such as those involved in HER-kinase axis pathway, in a multiplex format. This will allow physicians to determine the efficacy of relevant chemotherapy in real time. Combined with a different set of tumor markers, the new protein assays will also allow physicians to detect cancer early, e.g., stage 1 ovarian cancer, so that cancer survival rates can be improved greatly with early intervention. Combined with yet another set of protein markers such as CDKN1A, CRP, and H2AX, this new tool will permit the rapid triaging of individuals with <2 Gy, and >2 Gy exposure in mass radiation exposure scenarios. We have now successfully applied magneto-nano biochips based on giant magnetoresistance (GMR) spin valve sensor arrays and magnetic nanoparticle labels (nanotags) to the detection of biological events in the form of multiplex protein assays (4- to 64-plex) with great speed (30 min. – 2 hours), sensitivity (1 picogram/milliliter concentration levels or below), selectivity, and economy [1,2]. The technology is highly scalable to deep multiplex detection of biomarkers in a complex disease, and amenable to integration of microfluidics and CMOS electronics for portable applications. This platform technology is ideal for measuring multiple protein levels in a volume of only 10-50 uL of serum sample from a human patient with minimal invasiveness, either in a laboratory setting or at point of care.
 Gaster RS, Hall DA, Nielsen CH, Osterfeld SJ, Yu H, Mach KE, WilsonRJ, Murmann B, Liao JC, Gambhir SS, and Wang SX, Nature Medicine, 15, 1327-1332, 2009.
 Osterfeld SJ, Yu H, Gaster RS, Caramuta S, Xu L, Han SJ, Hall DA, Wilson RJ, Sun S, White RL, Davis RW, Pourmand N, Wang SX , PNAS, 105, 20637-20640, 2008.
Dr. Wang currently serves as the director of the Stanford Center for Magnetic Nanotechnology and is a full professor in the Department of Materials Science & Engineering and jointly in the Department of Electrical Engineering at Stanford University. He is a Co-Leader of the Stanford-led Center for Cancer Nanotechnology Excellence focused on Therapeutic Responses (CCNE-TR), and the principal investigator of the rapid and accurate proteomic index dosimetry (RAPID) consortium including Stanford University and Lawrence Berkeley National Lab. He is also with the Geballe Laboratory for Advanced Materials, and is affiliated with Stanford Bio-X Program and Cardiovascular Institute. His current research interests lie in magnetic nanotechnologies and information storage in general and include magnetic biochips, magnetic nanoparticles, nano-patterning, spin electronic materials and sensors, magnetic inductive heads, as well as magnetic integrated inductors and transformers. He has published over 170 papers, and holds 24 patents (issued and pending) on these subjects. Dr. Wang contributed two books and three book chapters on magnetic biochip, nanoparticles, information storage, and embedded inductors, respectively, and gave more than 60 invited presentations in major scientific conferences and meetings, and his work received media coverage from ABC TV, Economist, San Jose Mercury News, Technology Review, EE Times, ScienceWatch, People’s Daily and the like. Dr. Wang was an inaugural Frederick Terman Faculty Fellow at Stanford University (94-97), an IEEE Magnetics Society Distinguished Lecturer (2001-2002), and was elected an IEEE Fellow (2009). He also received the Obducat Prize for 2007-8, a National Academies Keck Futures Initiative Award (2006), an IBM Partnership Award in 1999, and was selected to the CUSPEA program organized by Nobel Laureate T. D. Lee in 1986. His students have won BMEidea Competition 1st Prize and IEEE President’s Change the World Competition 1st Prize (2009). Prof. Wang received the B.S. degree in physics from the University of Science and Technology of China in 1986, the M.S. in physics from Iowa State University in 1988, and the Ph.D. in electrical and computer engineering from the Carnegie Mellon University (CMU) at Pittsburgh in 1993.
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